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Related Experiment Videos

[Tumor necrosis factor].

I Urushizaki, Y Niitsu, N Watanabe

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Tumor necrosis factor (TNF), a macrophage-derived cytokine, demonstrates significant antitumor effects and tumor specificity. This review explores the mechanism of action for recombinant human TNF (rH-TNF) in cancer therapy.

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    Area of Science:

    • Biotechnology and Immunology

    Context:

    • Tumor necrosis factor (TNF) is a cytokine with potential in cancer therapy due to its antitumor effects and tumor specificity.
    • Recombinant human TNF (rH-TNF) can now be produced on a large scale, enabling clinical studies.

    Purpose:

    • To review the mechanism of action of recombinant human TNF (rH-TNF) against tumors.
    • To elucidate the cytotoxic activity of rH-TNF in both in vitro and in vivo models.

    Summary:

    • The gene for human TNF has been successfully expressed in E. coli, and the recombinant protein (rH-TNF) purified using various chromatography techniques.
    • Large-scale production of rH-TNF has facilitated clinical trials, highlighting its therapeutic promise.
    • Despite observed antitumor effects, the precise mechanisms underlying rH-TNF's cytotoxic activity remain under investigation.

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    Impact:

    • Provides a comprehensive review of rH-TNF's mechanism of action in cancer treatment.
    • Highlights the need for further research into the cytotoxic pathways of rH-TNF.
    • Contributes to the understanding of cytokine-based cancer therapies.