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Sleep disorders in primary antiphospholipid syndrome
Luana Viana de Oliveira1, Nailú Angélica Sinicato2, Simone Appenzeller3
1Rheumatology Division, Clinical Hospital, Faculty of Medical Science, University of São Paulo, São Paulo, Brazil.
Clinical Rheumatology
|October 21, 2018
Summary
Patients with primary antiphospholipid syndrome (pAPS) experience significantly poorer sleep quality compared to healthy individuals. This study found no specific clinical or laboratory factors linked to sleep disturbances in pAPS patients.
Area of Science:
- Rheumatology
- Sleep Medicine
- Immunology
Background:
- Primary antiphospholipid syndrome (pAPS) is an autoimmune condition.
- Sleep disturbances are common in chronic illnesses but understudied in pAPS.
- Understanding sleep quality in pAPS is crucial for patient well-being.
Purpose of the Study:
- To assess sleep quality in patients with pAPS.
- To identify the prevalence of sleep disorders in pAPS.
- To explore associations between sleep quality and clinical/laboratory features in pAPS.
Main Methods:
- Cross-sectional study design.
- Involved 40 consecutive pAPS patients and 211 healthy controls.
- Utilized the Pittsburgh Sleep Quality Index (PSQI) for sleep assessment.
Main Results:
- pAPS patients reported significantly worse overall sleep quality than controls.
- Worse scores were observed in sleep duration, efficiency, disturbance, medication use, and daytime somnolence.
- No significant associations were found between sleep disturbance and demographic, clinical, or laboratory features of pAPS.
Conclusions:
- This is the first study to demonstrate significantly impaired sleep quality in pAPS patients.
- Despite poor sleep, no specific disease characteristics were identified as predictors of sleep disturbance.
- Further research may be needed to understand the underlying mechanisms of sleep issues in pAPS.
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