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Identification of Circular RNAs using RNA Sequencing
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Circular RNA in cardiovascular disease.

M-Ashraf Altesha1, Tiffany Ni2, Afaan Khan3

  • 1Department of Pathology, Western University, Ontario, Canada.

Journal of Cellular Physiology
|October 21, 2018
PubMed
Summary

Circular RNAs (circRNAs), stable molecules, are increasingly linked to cardiovascular diseases. This review covers their biogenesis, detection, and roles in heart conditions, highlighting their biomarker potential.

Keywords:
biogenesiscardiovascular diseasecircular RNAmiRNA sponge

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • Circular RNAs (circRNAs) are unique RNA molecules with enhanced stability due to their closed-loop structure.
  • Their differential expression across various conditions suggests significant biological roles.
  • Emerging evidence points to circRNAs involvement in the development of cardiovascular diseases.

Purpose of the Study:

  • To provide a comprehensive overview of circular RNA biogenesis, properties, and detection methods.
  • To summarize the expression profiles and functions of circRNAs.
  • To elucidate the implication of circRNAs in various cardiac pathologies.

Main Methods:

  • Literature review and synthesis of current research on circRNAs.
  • Analysis of circRNA biogenesis pathways and stability factors.
  • Compilation of data on circRNA expression in cardiovascular disease models and patients.

Main Results:

  • CircRNAs exhibit distinct expression patterns and possess unique functional properties.
  • Various methods for circRNA detection and quantification have been developed.
  • CircRNAs play critical roles in the pathogenesis of ischemia reperfusion injury, myocardial infarction, cardiac senescence, fibrosis, cardiomyopathy, hypertrophy, heart failure, atherosclerosis, coronary artery disease, and aneurysm.

Conclusions:

  • Circular RNAs are significant regulators in cardiovascular pathophysiology.
  • Their stability and specific expression profiles make them promising diagnostic biomarkers and therapeutic targets for heart diseases.
  • Further research into circRNA mechanisms will advance cardiovascular medicine.