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Ocular involvement associated with chronic Epstein-Barr virus disease
Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 1, 1987
Summary
Chronic Epstein-Barr virus infection can cause severe eye problems, including uveitis and keratitis. Prompt treatment with antiviral and anti-inflammatory medications can help manage these ocular manifestations.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Virology
Background:
- Ocular manifestations of acute Epstein-Barr virus infection are typically mild conjunctivitis.
- Chronic Epstein-Barr virus infection is increasingly recognized, but its ocular effects are under-documented.
Observation:
- Three patients with chronic Epstein-Barr virus infection presented with significant ocular involvement.
- Ocular findings included bilateral uveitis, ranging from anterior uveitis to severe panuveitis.
Findings:
- Severe cases involved vitritis, cataract, optic disc swelling, and macular edema.
- Treatment with systemic and topical acyclovir improved inflammatory reactions.
- Topical steroids resolved keratitis, and surgery addressed cataract and vitreous issues.
Implications:
- Chronic Epstein-Barr virus infection should be considered in patients with unexplained uveitis or other severe ocular conditions.
- Antiviral and anti-inflammatory therapies, potentially combined with surgical interventions, are crucial for managing ocular complications.
- Further research is needed to fully understand the spectrum and management of ocular disease in chronic Epstein-Barr virus infection.