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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

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Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta

Johanna P Laakkonen1, Johanna Lähteenvuo1, Suvi Jauhiainen1

  • 1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

Vascular Pharmacology
|October 21, 2018
PubMed

Vascular endothelial growth factors regulate vascular and lymphatic growth. Dysregulation of VEGF signaling is connected to many pathological states, including hemangiomas, arteriovenous malformations and placental abnormalities. In heart, VEGF gene transfer induces myocardial angiogenesis. Besides vascular and lymphatic endothelial cells, VEGFs affect multiple other cell types. Understanding VEGF biology and its paracrine signaling properties will offer new targets for novel treatments of several diseases.

Keywords:
AngiogenesisArteriovenous malformationHeartHemangiomaLymphangiogenesisLymphatic vesselPlacentaVEGFVEGF receptorVascular endothelial growth factorVascular tumor

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