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Updated: Feb 3, 2026

Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior
Published on: March 8, 2024
Selective adsorption and removal of drug contaminants by using an extremely stable Cu(II)-based 3D metal-organic
Weicong Liu1, Xin Shen1, Yaoyao Han1
1Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China.
Abstract:
The adsorption capacity of three representative pharmaceutical drugs and personal care products (PPCPs) viz. diclofenac sodium (DCF), chlorpromazine hydrochloride (CLF) and amodiaquin dihydrochloride (ADQ), were preliminarily studied using a water-stable Cu(II)-based metal organic framework (MOF) [Cu(BTTA)]n·2DMF (1) (H2BTTA = 1,4-bis(triazol-1-yl)terephthalic acid). We also investigated the factors influencing the adsorption such as concentration, pH, contact time, temperature and dosages. The results show that the adsorption capacity of 1 for DCF (650 mg g-1) from aqueous medium, which is higher in comparison to most of the reported MOFs. While the adsorption of CLF and ADQ are only 67 mg g-1 and 72 mg g-1, respectively. The adsorption isotherm and adsorption kinetics indicated that the adsorption of diclofenac sodium by 1 follows Freundlich model with R2 value of 0.9902 and pseudo-first-order kinetics with correlation coefficient 0.9939 and K1 value of 0.0058 min-1, respectively. Investigations indicate that 1 could become a potential material to adsorb DCF from aqueous medium.
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