Related Experiment Video
Updated: Feb 3, 2026
14:32
Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
8.6K
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
Yijie Wang1, Jun He1, Mengya Liao2
1State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
European Journal of Medicinal Chemistry
|October 21, 2018
Summary
Sirtuins, enzymes utilizing nicotinamide adenine dinucleotide (NAD+), are crucial in regulating cellular processes and are linked to aging diseases. This review covers Sirtuin structure, function, and modulators for future research.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Sirtuins (Yeast Silent Information Regulators II, Sir2) were discovered in the 1970s.
- These enzymes utilize nicotinamide adenine dinucleotide (NAD+) to remove acetyl groups from histones.
- Sirtuins are implicated in aging-related diseases, including cardiovascular disorders, neurodegeneration, and cancer.
Purpose of the Study:
- To provide a comprehensive review of Sirtuin family members.
- To detail the structure, function, and modulators of Sirtuins.
- To highlight the therapeutic potential of Sirtuins.
Main Methods:
- Literature review of Sirtuin research.
- Analysis of Sirtuin structure and enzymatic activity.
- Compilation of known Sirtuin modulators.
Main Results:
- The Sirtuin family comprises seven human isoforms (Sirt1-Sirt7).
- Sirtuins play diverse roles in cellular regulation beyond histone deacetylation.
- Numerous compounds and conditions modulate Sirtuin activity.
Conclusions:
- Sirtuins represent a promising therapeutic target for aging-related diseases.
- Further research into Sirtuin structure, function, and modulation is warranted.
- Understanding Sirtuins can benefit studies on aging and disease.
More Related Videos
Related Concept Videos
01:15Overview of Myosin Structure and Function
6.6K
Myosins are a family of molecular motor proteins, first identified in the skeletal muscles, where they are responsible for muscle contraction. Along with their role in muscle contraction, these proteins also play a role in the intracellular transport of molecules and vesicles. There are twenty-four classes of myosins based on their domain sequence and organization. Of the twenty-four, six classes (Myosin I, Myosin II, Myosin V, Myosin VI, Myosin VII, and Myosin X) have been well...
6.6K
01:56Structural Protein Function
30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
30.0K
01:19Overview of Functional Groups
15.8K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, certain functional groups will make a molecule hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each functional group is a unique...
15.8K
01:58Fruit Development, Structure, and Function
25.2K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.2K
01:16Therapeutic Drug Monitoring: Overview and Classification
347
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
347
01:26Targets for Drug Action: Overview
10.3K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.3K