Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Changes in the Appendicular Skeleton with Age

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Long-Acting Combination Nerve Block in Rhinoplasty to Minimize Postoperative Opioid Use.

Aesthetic surgery journal. Open forum·2026

Same author

Partial Submandibular Gland Resection With Ultrasonic Dissector vs Electrocautery.

Aesthetic surgery journal. Open forum·2025

Same author

Pyriform Aperture Enlargement Through a Rhinoplasty Approach.

Aesthetic surgery journal. Open forum·2025

Same author

Imbrication of Anterior Digastric with Advancement of the Posterior Digastric and Its Implications in Neck Aesthetics.

Facial plastic surgery & aesthetic medicine·2023

Same author

The Use of Adjunctive Perioperative Nerve Blocks in Rhinoplasty in the Immediate Postoperative Period.

Facial plastic surgery & aesthetic medicine·2022

Same author

In-office Endonasal Minor Revision Rhinoplasty.

Facial plastic surgery : FPS·2021

Same journal

Care Transitions Continue to Evolve.

The Medical clinics of North America·2026

Same journal

Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

The Medical clinics of North America·2026

Same journal

Care Transitions and Value-Based Payment Models in the United States.

The Medical clinics of North America·2026

Same journal

Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

The Medical clinics of North America·2026

Same journal

Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

The Medical clinics of North America·2026

Same journal

Social Determinants of Health: Unique Considerations in Transitions of Care.

The Medical clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 3, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

The Aging Face.

Anil R Shah¹, Paige M Kennedy¹

¹Department of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine, The University of Chicago Medicine and Biological Sciences, 5841 South Maryland Avenue, Room E-103, MC1035, Chicago, IL 60637, USA.

The Medical Clinics of North America

|October 22, 2018

Summary

This summary is machine-generated.

Understanding facial aging is key to effective treatment. This article explores the causes, prevention, and various surgical and nonsurgical options for addressing age-related facial changes.

Keywords:

Antiaging Cosmetic surgery Facial aging Fillers Implants Laser therapy Rhytids

More Related Videos

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Related Experiment Videos

Last Updated: Feb 3, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Area of Science:

Gerontology and Aesthetic Medicine

Background:

Facial aging is a significant concern in modern medicine.
Understanding the biological and physical factors of facial aging is crucial.

Purpose of the Study:

To explore the causes and contributing factors of facial aging.
To discuss preventative measures against advanced facial aging.
To review current surgical and nonsurgical treatment options.

Main Methods:

Review of the aging process.
Discussion of various treatment modalities.

Main Results:

Facial aging is a progressive process.
Numerous methods exist to mitigate signs of aging.
Both surgical and nonsurgical treatments are available.

Conclusions:

Comprehensive understanding of facial aging is essential for treatment.
A variety of options can help patients achieve desired aesthetic outcomes.