Related Experiment Video
Updated: Feb 3, 2026
07:15
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
11.4K
Standardized Immunomonitoring: Separating the Signals from the Noise
1Dendritic Cell Immunobiology Unit, Institut Pasteur, Paris, France; INSERM U1223, Paris, France.
Trends in Biotechnology
|October 23, 2018
Summary
New protein assays and standardized immune stimulation methods can improve clinical immune response monitoring. These advances are key for adopting precision medicine strategies in healthcare.
Area of Science:
- Clinical immunology
- Biomarker discovery
- Precision medicine
Background:
- Classical immunoassays are standard for disease diagnosis and monitoring.
- Advanced phenotyping technologies can broaden immune response monitoring.
- Clinical translation of novel immune monitoring tools faces challenges.
Purpose of the Study:
- To discuss strategies for advancing the clinical adoption of immune-based biomarkers.
- To highlight methods for improving the reliability and utility of immune response monitoring in clinical settings.
Main Methods:
- Focus on protein-based assays with digital readouts to minimize nonspecific signals.
- Describe standardized immune stimulation approaches to reveal disease-specific signatures.
- Emphasize integrating immune response phenotypes for clinical applications.
Main Results:
- Digital readouts in protein assays reduce limitations of classical methods.
- Standardized stimulation enhances detection of disease-specific immune responses.
- Improved immune phenotyping is crucial for precision medicine.
Conclusions:
- Protein-based digital assays and standardized immune stimulation are promising for clinical use.
- These strategies can overcome current limitations in immune monitoring.
- Integrating immune phenotypes is essential for advancing precision medicine.
Related Concept Videos
02:37Standard Enthalpy of Formation
49.2K
Enthalpy changes are typically tabulated for reactions in which both the reactants and products are at the same conditions. A standard state is a commonly accepted set of conditions used as a reference point for the determination of properties under other different conditions. For chemists, the IUPAC standard state refers to materials under a pressure of 1 bar and solutions at 1 M and does not specify a temperature. Many thermochemical tables list values with a standard state of 1 atm. Because...
49.2K
03:02Standard Electrode Potentials
50.3K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.3K
03:38Measurement: Standard Units
79.9K
Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
79.9K
02:49Calculating Standard Free Energy Changes
24.9K
The free energy change for a reaction that occurs under the standard conditions of 1 bar pressure and at 298 K is called the standard free energy change. Since free energy is a state function, its value depends only on the conditions of the initial and final states of the system. A convenient and common approach to the calculation of free energy changes for physical and chemical reactions is by use of widely available compilations of standard state thermodynamic data. One method involves the...
24.9K
01:14Standard Solutions
2.5K
Standard solutions refer to solutions with a precisely known concentration or composition. A primary standard is a highly pure, high molar mass, stable substance that is entirely soluble in water, the most commonly used solvent in analytical chemistry. The primary standard solution can be used to standardize secondary standards, which are substances with known concentrations but are less pure and stable. Standard solutions are essential for achieving accurate and reliable results in analytical...
2.5K
01:26Standard Precaution
3.0K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
3.0K