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The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis

Milos Stulic1, Djordje Culafic2, Radmila Obrenovic3

  • 1Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. drstulic@gmail.com.

Medicina (Kaunas, Lithuania)
|October 23, 2018
PubMed

Insights

Hepatic artery resistive index (HARI) more accurately identifies liver fibrosis than cystatin C (CysC). However, CysC better indicates the severity of liver cirrhosis progression.

Area of Science:

  • Hepatology
  • Nephrology
  • Medical Diagnostics

Background:

  • Cystatin C (CysC) and hepatic artery resistive index (HARI) are potential biomarkers for chronic liver disease progression.
  • Assessing their clinical utility in liver cirrhosis is crucial.

Purpose of the Study:

  • To evaluate the clinical significance of CysC and HARI in assessing liver fibrosis in patients with liver cirrhosis.
  • To compare the efficacy of CysC and HARI in differentiating healthy individuals from those with liver fibrosis.

Main Methods:

  • A cross-sectional study involving 63 liver cirrhosis patients and 30 healthy controls.
  • Measurement of CysC levels and HARI values.
  • Statistical analysis including correlation and receiver operating characteristic (ROC) curve analysis.

Main Results:

  • Significantly higher CysC levels and increased HARI values were observed in liver cirrhosis patients compared to controls (p=0.036 and p<0.001, respectively).
  • A significant correlation was found between HARI and CysC in the study group.
  • HARI demonstrated a greater area under the curve than CysC for distinguishing healthy subjects from patients with fibrosis.
  • CysC showed statistically significant correlations with Child-Pugh stages and MELD score.

Conclusions:

  • HARI is a more accurate parameter than CysC for discriminating healthy individuals from those with liver fibrosis.
  • CysC may serve as a better indicator for assessing the stage of liver cirrhosis.
Abstract

Keywords:
Cystatin Chepatic artery resistive indexliver cirrhosis

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