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Association between Adverse Effects and Parental Beliefs about Antiepileptic Medicines

Violeta Ilić1, Dragana Bogićević2, Branislava Miljković3

  • 1Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia. ilicvioleta@yahoo.com.

Medicina (Kaunas, Lithuania)
|October 23, 2018
PubMed

Insights

Adverse effects of antiepileptic drugs in children are linked to parental beliefs about medication. Understanding this connection can improve educational programs for parents regarding antiepileptic drug use.

Area of Science:

  • Pediatric Neurology
  • Pharmacology
  • Psychology

Background:

  • Adverse effects are common in children treated with antiepileptic medications.
  • These effects can influence parental beliefs regarding treatment efficacy and necessity.
  • Understanding the interplay between side effects and parental beliefs is crucial for optimizing pediatric epilepsy management.

Purpose of the Study:

  • To investigate the relationship between adverse effects experienced by children and their parents' beliefs about antiepileptic drugs (AEDs).
  • To explore how specific adverse effects correlate with parental perceptions of AED necessity and concerns.
  • To inform the development of targeted educational strategies for parents of children on AEDs.

Main Methods:

  • A study involving 127 children treated with valproic acid, carbamazepine, or lamotrigine at a University Children's Hospital.
  • Parents completed the Beliefs about Medications Questionnaire (BMQ) and The Liverpool Adverse Events Profile (LAEP).
  • Statistical analysis was used to correlate reported adverse effects with parental beliefs and demographic factors.

Main Results:

  • Nervousness, weight gain, restlessness, headache, difficulty concentrating, aggression, and upset stomach were the most frequent adverse effects.
  • Parental education level correlated with BMQ-specific necessity scores.
  • Difficulty concentrating was associated with higher parental concern and necessity scores, while headaches correlated with higher general overuse scores.

Conclusions:

  • Parental beliefs about antiepileptic drugs are significantly associated with the presence of adverse effects in children.
  • Physicians and pharmacists can use this understanding to tailor educational programs for parents.
  • Focused education on AED side effects can alleviate parental concerns and reinforce the perceived necessity of medication.

Keywords:
adverse eventsantiepileptic drugsbeliefs about medicationschildrenparents

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