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Changes and correlations of serum interleukins, adhesion molecules and soluble E-selectin in children with allergic

Jing Bi1, Yaoqin Hu2, Zhaoyang Peng3

  • 1Jing Bi, Department of Otolaryngology Head and Neck Surgery, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, Zhejiang Province, China.

Pakistan Journal of Medical Sciences
|October 23, 2018
PubMed

Insights

Serum biomarkers like interleukins (ILs) and adhesion molecules are elevated in children with allergic rhinitis and asthma. These markers, including soluble E-selectin (sE-selectin), can help assess the severity of these respiratory allergic conditions.

Area of Science:

  • Immunology
  • Pediatric Allergy
  • Biochemistry

Background:

  • Allergic rhinitis and asthma are common pediatric respiratory conditions.
  • Understanding the underlying immunological mechanisms is crucial for diagnosis and management.
  • Biomarkers can offer insights into disease activity and progression.

Purpose of the Study:

  • To investigate changes in serum interleukins (ILs), adhesion molecules, and soluble E-selectin (sE-selectin).
  • To examine correlations between these markers in children with allergic rhinitis, asthma, and combined conditions.
  • To assess the potential of these biomarkers in evaluating respiratory allergic diseases.

Main Methods:

  • Serum levels of IL-4, IL-5, IL-10, sICAM-1, sVCAM-1, and sE-selectin were measured in children with allergic rhinitis, asthma, both, and healthy controls.
  • Double-antibody sandwich ELISA was employed for detection.
  • Spearman's correlation analysis was used to determine relationships between markers.

Main Results:

  • All three patient groups showed significantly higher serum IL levels compared to controls.
  • The complication group had higher IL levels than the asthma group, and higher IL-5 and IL-10 than the allergic rhinitis group.
  • Significantly elevated serum sICAM-1, sVCAM-1, and sE-selectin were observed in all patient groups compared to controls, with the complication group showing the highest levels.

Conclusions:

  • Serum IL-4, IL-5, IL-10, adhesion molecules, and sE-selectin play a role in the pathogenesis of allergic rhinitis and asthma.
  • These biomarkers can serve as indicators for assessing the severity of pediatric respiratory allergic diseases.
Abstract

Keywords:
Adhesion moleculeAllergic rhinitisAsthmaE-selectinInterleukin

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