Related Experiment Video

Updated: Feb 3, 2026

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
08:49

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

11.7K

Durvalumab in NSCLC: latest evidence and clinical potential

Nerea Muñoz-Unceta1, Isabel Burgueño1, Elizabeth Jiménez1

  • 1Medical Oncology Department, Hospital Universitario 12 de Octubre and Instituto de Investigación i+12, Madrid, Spain.

Therapeutic Advances in Medical Oncology
|October 23, 2018
PubMed

Insights

Immunotherapy, including durvalumab targeting programmed death ligand 1, significantly improves outcomes in non-small cell lung cancer (NSCLC). Ongoing trials explore its use alone and in combination across various disease stages.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Immunotherapy has revolutionized cancer treatment, notably improving survival in non-small cell lung cancer (NSCLC) with metastatic disease using immune checkpoint inhibitors.
  • Recent advances show promise in earlier stages of NSCLC, with combinations of therapies under active investigation.

Purpose of the Study:

  • To highlight the efficacy and safety of durvalumab, an antibody targeting programmed death ligand 1 (PD-L1), in NSCLC treatment.
  • To summarize ongoing clinical investigations of durvalumab in various NSCLC stages and therapeutic combinations.

Main Methods:

  • Review of clinical trial data and outcomes for durvalumab in NSCLC.
  • Analysis of durvalumab's safety profile in combination with chemotherapy, radiotherapy, and other immunotherapies.

Main Results:

  • Durvalumab demonstrated significant activity in NSCLC, improving progression-free survival in unresectable stage III disease post-chemoradiation.
  • The treatment exhibited a favorable safety profile.

Conclusions:

  • Durvalumab is an effective immunotherapy for NSCLC, showing benefits in both metastatic and earlier disease settings.
  • Further research, including Phase III trials, is evaluating durvalumab as monotherapy and in combination regimens for diverse NSCLC stages.
Keywords:
PD-L1 expression testingcheckpoint inhibitorsimmunotherapylung cancerpredictive biomarkerradiotherapytumour mutational burden

More Related Videos

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration14:49

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Published on: September 29, 2018

42.5K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.2K

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.2K
Potential Energy00:52

Potential Energy

The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
Potential Energy01:09

Potential Energy

A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
1.0K
Standard Electrode Potentials03:02

Standard Electrode Potentials

On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.3K
Cell Potential and Free Energy02:58

Cell Potential and Free Energy

Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.5K
The Resting Membrane Potential01:21

The Resting Membrane Potential

Overview
142.6K