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Updated: Feb 3, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Bayesian Design of Non-Inferiority Clinical Trials via the Bayes Factor
Wenqing Li1, Ming-Hui Chen2, Xiaojing Wangy2
1Ventana Medical Systems, Inc., 1910 East Innovation Park Drive, Tucson, AZ 85755, USA.
Abstract:
We developed a Bayes factor based approach for the design of non-inferiority clinical trials with a focus on controlling type I error and power. Historical data are incorporated in the Bayesian design via the power prior discussed in Ibrahim and Chen (2000). The properties of the proposed method are examined in detail. An efficient simulation-based computational algorithm is developed to calculate the Bayes factor, type I error and power. The proposed methodology is applied to the design of a non-inferiority medical device clinical trial.
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