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Related Experiment Video

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A Small Volume Bioassay to Assess Bacterial/Phytoplankton Co-culture Using WATER-Pulse-Amplitude-Modulated WATER-PAM Fluorometry
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[Epidermodysplasia verruciformis: about a case].

Fatima-Zahra Agharbi1

  • 1Hôpital Civil Tétouan, Tétouan, Maroc.

The Pan African Medical Journal
|October 23, 2018
PubMed
Summary

Epidermodysplasia verruciformis is a rare genetic skin disorder causing susceptibility to human papillomaviruses (HPVs). This case highlights a 30-year-old man with early-onset lesions and discusses management strategies.

Area of Science:

  • Dermatology
  • Genetics
  • Virology

Background:

  • Epidermodysplasia verruciformis (EV), or Lewandowsky-Lutz syndrome, is a rare genodermatosis.
  • It is characterized by extreme susceptibility to specific human papillomaviruses (HPVs).
  • EV typically manifests in childhood with scaly macules and papules, primarily on extremities.

Observation:

  • The case involves a 30-year-old male with verrucous and pityriasis versicolor-like lesions since age 4.
  • Clinical examination revealed no suspicious lesions indicative of malignancy.
  • The patient was initiated on retinoid therapy.

Findings:

  • Human Papillomavirus types 5 and 8 are frequently implicated in EV lesions.
  • While common in the general population, these HPV types are pathogenic in EV patients.
Keywords:
EpidermodysplasiaHPVcarcinomasverruciformis

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  • The disorder carries a significant risk of malignant transformation to squamous cell carcinoma.

    • Implications:

    • Current treatments for EV, including retinoids and interferon, show limited and inconsistent efficacy.
    • Management emphasizes sun protection, vigilant clinical monitoring, and prompt surgical removal of malignant lesions.
    • This case underscores the importance of early diagnosis and ongoing management of EV.