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Applications of Integration to Find Blood Flow

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Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...

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Related Experiment Video

Updated: Feb 3, 2026

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

Integrated Lateral Flow Device for Flow Control with Blood Separation and Biosensing.

Veronica Betancur¹, Jianbo Sun², Nianqiang Wu¹

¹Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV 26506, USA.

|October 23, 2018

Summary

This study presents an integrated lateral flow device (LFD) using capillary forces and functionalized microfluidics for portable diagnostics. The device enables controlled blood plasma flow and biomarker detection, offering a versatile platform for point-of-care testing.

Keywords:

flow control integration of functions lateral flow device polydimethylsiloxane (PDMS) surface modification

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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

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Published on: March 22, 2012

Area of Science:

Microfluidics and Lab-on-a-Chip Technology
Biosensing and Diagnostic Devices
Biomarker Detection and Immunoassays

Background:

Lateral flow devices (LFDs) are versatile but face limitations in flow control and sensor integration for sensitive molecular detection.
Point-of-care (POC) applications offer significant diagnostic potential, yet require simplified, self-powered, and portable solutions.
Paper-based LFDs are low-cost but present challenges in precise flow rate tuning and assay functionalization.

Purpose of the Study:

To develop an integrated, portable, and self-powered lateral flow device (LFD) utilizing capillary forces and functionalized polymer microfluidics.
To achieve controlled plasma flow rates for enhanced immunoassay performance.
To demonstrate the detection of biomarkers from whole blood using an integrated nanoelectronic sensor.

Main Methods:

Fabrication of a polydimethylsiloxane (PDMS) microfluidic device functionalized with Pluronic F127 to control surface hydrophilicity.
Integration of a plasma separation membrane for efficient sample processing from human whole blood.
Utilized capillary forces and microfluidic design for controlled fluid flow, coupled with a graphene nanoelectronic sensor for biomarker (IgG) detection.

Main Results:

Successfully demonstrated a portable, self-powered LFD capable of controlled plasma flow rates.
Achieved high-quality plasma separation from whole blood using an asymmetric membrane.
Validated biomarker immunoglobulin G (IgG) detection from plasma using the integrated graphene nanoelectronic sensor.

Conclusions:

The developed integrated LFD offers a flexible and versatile platform for detecting circulating biomarkers directly from whole blood.
This bio-sensing technology provides a viable alternative for point-of-care testing, particularly benefiting resource-limited healthcare settings.
The platform supports various sensing modalities and immunoassay formats, highlighting its broad applicability in diagnostics.