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The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain

Fatma Sarac1, Sevgi Buyukbese Sarsu2, Selman Yeniocak3

  • 1Department of Pediatric Surgery, Haseki Research and Education Hospital, Istanbul, Turkey.

Emergency Medicine International
|October 23, 2018
PubMed

Insights

Irisin, a peptide hormone, shows potential as a biomarker for diagnosing acute appendicitis (AA) and perforated appendicitis (PA) in children. Elevated irisin levels help differentiate these conditions from other causes of acute abdominal pain.

Area of Science:

  • Pediatric Emergency Medicine
  • Gastroenterology
  • Biomarker Discovery

Background:

  • Diagnosing acute abdominal pain in pediatric patients presents clinical challenges.
  • Accurate differentiation is crucial for timely surgical intervention.

Purpose of the Study:

  • To evaluate the efficacy of irisin as a diagnostic biomarker.
  • To differentiate acute appendicitis (AA) and perforated appendicitis (PA) in children presenting with acute abdominal pain.

Main Methods:

  • A cohort of 112 pediatric patients with acute abdominal pain and 50 controls were enrolled.
  • Blood samples were analyzed for irisin, white blood cell (WBC) count, and C-reactive protein (CRP) levels.

Main Results:

  • Mean irisin levels were significantly higher in patients with AA and PA compared to controls and nonspecific abdominal pain.
  • WBC and CRP levels were also elevated in AA and PA cases.
  • No significant difference in irisin levels was found between AA and PA.

Conclusions:

  • Irisin may serve as a valuable biomarker in the differential diagnosis of acute abdominal pain in pediatric patients.
  • This can aid in distinguishing appendicitis from other abdominal conditions, potentially improving surgical decision-making.
Abstract

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