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Updated: Feb 3, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure
Jonel Trebicka1,2,3,4, Thomas Reiberger5,6, Wim Laleman7,8
1Department of Internal Medicine I, University of Bonn, Bonn, Germany.
Abstract:
Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver disease, with systemic inflammation playing a central role. Portal hypertension (PHT) is also aggravated by inflammation and may subsequently impact the course of ACLF. PHT is more than just an increase in portal pressure in the portal venous system; it aggravates the course of liver disease and, thus, also facilitates the development of acute decompensation and ACLF. A critical mechanistic link between PHT and ACLF might be the gut-liver axis, which is discussed in this review.
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