Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microtubule Associated Proteins (MAPs)01:42

Microtubule Associated Proteins (MAPs)

5.9K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
5.9K
Plotting of Topographic Maps01:29

Plotting of Topographic Maps

525
Topographic maps represent the Earth's surface features using contour lines, which connect points of equal elevation to create a two-dimensional representation of three-dimensional terrain. Creating a topographic map requires a systematic approach.Begin by plotting a scaled grid and marking intersections corresponding to the survey's elevation data points. Assign elevation values at these intersections to build the base map. Next, determine contour levels using a consistent contour interval,...
525
Coordinates and Map Projections01:29

Coordinates and Map Projections

614
Coordinates and map projections are essential tools in accurately representing the Earth's surface for various applications, ranging from navigation to spatial analysis. The latitude and longitude coordinate system is a universally recognized framework for defining locations. Latitude specifies the distance of a point north or south of the equator, measured in degrees from 0° at the equator to 90° at the poles. Longitude indicates a location's position east or west of the prime meridian,...
614
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.6K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.6K
tRNA Activation02:26

tRNA Activation

22.9K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
22.9K
Activation Energy01:26

Activation Energy

86.6K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
86.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surface circumferential spinal cord recording in freely moving rodents.

Nature communications·2026
Same author

Focal MRI-guided theta burst TMS in the common marmoset produces bidirectional corticospinal modulation.

Brain stimulation·2026
Same author

Design principles for π-conjugated hydrogel semiconductors.

Nature materials·2026
Same author

Body surface potential mapping of the cortico-muscular axis using smart textile electrode arrays.

Nature communications·2026
Same author

Hydration Effect of Glycopolymers on Lectin Recognition.

Biomacromolecules·2026
Same author

Dynamics of Intermediate Water in Biocompatible Poly(2-methoxyethyl acrylate) Revealed by Quasi-Elastic Neutron Scattering.

The journal of physical chemistry. B·2026

Related Experiment Video

Updated: Feb 3, 2026

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

2.4K

Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping.

Wonryung Lee1, Shingo Kobayashi2, Masase Nagase1,3

  • 1Department of Electrical Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Science Advances
|October 23, 2018
PubMed
Summary

Researchers developed a novel, stretchable multielectrode array (MEA) for high-fidelity, long-term electrocardiographic (ECG) monitoring of the heart. This device offers superior stretchability and non-thrombogenic properties for dynamic physiological applications.

More Related Videos

Multielectrode Array Recordings of the Vomeronasal Epithelium
08:27

Multielectrode Array Recordings of the Vomeronasal Epithelium

Published on: March 1, 2010

12.7K
A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires
07:50

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

Published on: January 21, 2016

10.4K

Related Experiment Videos

Last Updated: Feb 3, 2026

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

2.4K
Multielectrode Array Recordings of the Vomeronasal Epithelium
08:27

Multielectrode Array Recordings of the Vomeronasal Epithelium

Published on: March 1, 2010

12.7K
A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires
07:50

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

Published on: January 21, 2016

10.4K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Physiology

Background:

  • High-precision electrophysiological signal monitoring is crucial for understanding physiological functions.
  • Ultraflexible multielectrode arrays (MEAs) offer high spatial-temporal resolution but face challenges with stretchability and blood compatibility on dynamic organs like the heart.

Purpose of the Study:

  • To fabricate an active MEA with nonthrombogenicity, stretchability, and stability for long-term electrocardiographic (ECG) monitoring.
  • To overcome the limitations of existing MEAs for application on dynamic and bleeding organ surfaces.

Main Methods:

  • Fabrication of a novel stretchable MEA using organic electrochemical transistors on microgrid substrates.
  • Coating the MEA with poly(3-methoxypropyl acrylate) for antithrombotic properties and ionic conductivity.
  • Utilizing active data readout for enhanced signal quality.

Main Results:

  • The developed MEA demonstrated nonthrombogenicity, stretchability, and stability, enabling long-term ECG monitoring on rat hearts.
  • Achieved a high signal-to-noise ratio of 52 dB due to active data readout.
  • The material exhibited excellent antithrombotic properties while maintaining ionic conductivity.

Conclusions:

  • The novel stretchable MEA is suitable for long-term, high-precision ECG monitoring of dynamic organs, even in the presence of bleeding.
  • This technology advances the capabilities for in-vivo electrophysiological signal acquisition.
  • The combination of advanced materials and engineering provides a robust solution for cardiac monitoring.