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Updated: Feb 3, 2026

Non-equilibrium Microwave Plasma for Efficient High Temperature Chemistry
Published on: August 1, 2017
Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH
Daniel Bermejo-Velasco1, Ganesh N Nawale, Oommen P Oommen
1Translational Chemical Biology Laboratory, Division of Polymer Chemistry, Department of Chemistry-Ångstrom, Uppsala University, Uppsala, Sweden. oommen.varghese@kemi.uu.se.
Abstract:
We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling of biomolecules in an efficient and biocompatible manner.
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