Related Experiment Video
Updated: Feb 3, 2026
13:35
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
4.3K
Breast Implant-Associated Anaplastic Large Cell Lymphoma
P Rastogi1, A K Deva1, H Miles Prince2,3
1Department of Plastic, Reconstructive & Maxillofacial Surgery - Macquarie University, Sydney, New South Wales, Australia.
Current Hematologic Malignancy Reports
|October 23, 2018
Summary
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoma linked to textured implants. Research suggests a complex interplay of factors including bacteria and genetics contributes to its development and treatment.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell malignancy exclusively linked to textured breast implants.
- The exact incidence remains challenging to ascertain, with pathogenesis theories involving textured implants, Gram-negative bacteria, and host genetics.
Purpose of the Study:
- To review current understanding of BIA-ALCL epidemiology, pathogenesis, clinical evaluation, and management.
- To synthesize existing theories on the multifactorial etiology of BIA-ALCL.
Main Methods:
- Literature review of existing theories and clinical data on BIA-ALCL.
- Analysis of epidemiological trends, pathogenic mechanisms, and treatment outcomes.
Main Results:
- BIA-ALCL typically presents 8-10 years post-implantation with delayed seroma or capsular mass.
- Disease staging has shifted from a "liquid tumour" to a "solid tumour" model.
- Treatment varies by stage, including surgery, chemotherapy, radiotherapy, and targeted therapies like brentuximab vedotin.
Conclusions:
- The pathogenesis of BIA-ALCL involves a complex interplay of textured implants, bacterial biofilms, host genetics, and time.
- Further research into BIA-ALCL genetic mutations and immune responses to bacterial biofilms is warranted.
Related Concept Videos
01:07What are Cells?
199.6K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
199.6K
01:15What are Cells?
48.8K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
48.8K
02:03What is Cell Signaling?
130.4K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
130.4K
02:58Chemistry of the Cell
48.0K
The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
48.0K
02:41Concentration Cells
25.9K
A concentration cell is a type of a voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
Consider the following voltaic cell:
25.9K
01:22Hair Cells
45.0K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
45.0K