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Potential Uses of Sacubitril/Valsartan: Need for Data on Efficacy and Safety

Fabien Huet1,2, Mariama Akodad1,2, Eran Kalmanovitch1

  • 1Département de Cardiologie, Hôpital Arnaud de Villeneuve, CHU de Montpellier, UFR de Médecine, Université Montpellier 1, 371, avenue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France.

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
|October 23, 2018
PubMed

Insights

Sacubitril/valsartan (SV) shows promise beyond reduced ejection fraction heart failure, potentially benefiting preserved ejection fraction heart failure and chronic kidney disease. Further research is needed to address uncertainties for its widespread clinical use.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Nephrology

Background:

  • Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are established treatments for heart failure with reduced ejection fraction.
  • Emerging evidence suggests potential benefits of sacubitril/valsartan (SV) in other cardiovascular and renal conditions.

Purpose of the Study:

  • To review the emerging therapeutic applications of sacubitril/valsartan (SV) in heart failure with preserved ejection fraction and chronic kidney disease.
  • To discuss the potential limitations and challenges of implementing SV in routine clinical practice.

Main Methods:

  • Literature review of recent studies on sacubitril/valsartan (SV) efficacy in alternative indications.
  • Analysis of potential clinical pitfalls and areas of uncertainty regarding SV use.

Main Results:

  • Sacubitril/valsartan (SV) demonstrates promising efficacy in heart failure with preserved ejection fraction and chronic kidney disease.
  • Cognitive uncertainties and practical challenges may limit the immediate widespread adoption of SV in routine care.

Conclusions:

  • Sacubitril/valsartan (SV) represents a potential therapeutic advancement for conditions beyond its initial indication.
  • Addressing current uncertainties is crucial for optimizing the clinical utility of SV in diverse patient populations.

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