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The influence of interferon-γ on cardiac and renal histopathological changes induced by carbamazepine

S Bahmanpour, F Karimi, A Soleimani

    Bratislavske Lekarske Listy
    |October 23, 2018
    PubMed
    Abstract

    Insights

    Interferon-gamma (IFN-γ) mitigated fetal heart and kidney abnormalities caused by carbamazepine (CBZ) exposure in mice. This finding suggests IFN-γ may protect against CBZ-induced developmental toxicity.

    Area of Science:

    • Developmental toxicology
    • Immunology
    • Pharmacology

    Background:

    • Carbamazepine (CBZ) is a widely used antiepileptic drug.
    • CBZ exposure during pregnancy can lead to adverse fetal outcomes.
    • Investigating protective agents against drug-induced teratogenicity is crucial.

    Purpose of the Study:

    • To evaluate the protective effect of Interferon-gamma (IFN-γ) against carbamazepine (CBZ)-induced fetal histopathological changes.
    • To assess the impact of IFN-γ on fetal growth parameters in the context of CBZ exposure.

    Main Methods:

    • Pregnant mice were administered CBZ (240 mg/kg) or a combination of CBZ and IFN-γ.
    • Control groups received either distilled water or IFN-γ alone.
    • Fetal tissues (heart, kidney) were examined for histopathological alterations on day 18 of gestation.

    Main Results:

    • CBZ treatment significantly reduced fetal weight, crown-rump length, and organ volumes compared to controls.
    • IFN-γ administration, alone or with CBZ, did not cause adverse effects.
    • IFN-γ significantly prevented CBZ-induced histopathological damage in fetal heart and kidney.

    Conclusions:

    • Carbamazepine induces significant structural damage to fetal heart and kidney tissues.
    • Interferon-gamma demonstrates a protective role, reducing the teratogenic effects of carbamazepine.
    • IFN-γ holds potential as a therapeutic agent to mitigate CBZ-induced developmental toxicity.
    Keywords:
    carbamazepineheartinterferon-γkidney mice.

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