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Pharmacotherapeutic management of gout in patients with cardiac disease

Chun Wai Chan1, Ying Nee Yap2

  • 1a Department of Family Medicine , School of Medicine, International Medical University , Seremban , Negeri Sembilan Darul Khusus , Malaysia.

Expert Opinion on Pharmacotherapy
|October 23, 2018
PubMed

Insights

Hyperuricemia increases coronary artery disease (CAD) risk. While gout treatments exist, some, like NSAIDs, pose cardiac risks and should be avoided in CAD patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Pharmacology

Background:

  • Hyperuricemia is an independent risk factor for coronary artery disease (CAD).
  • Treatments for gout flares exist, but some carry cardiovascular risks.

Purpose of the Study:

  • To review the cardiac safety of traditional and novel gout medications.
  • To assess medication choices for gout patients with underlying CAD.

Main Methods:

  • Review of current international guidelines on gout management.
  • Analysis of cardiac safety profiles for various anti-gout medications.

Main Results:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) increase cardiac risk and should be avoided in CAD patients.
  • Interleukin-1 inhibitors are presented as safe alternatives for cardiac patients with gout.

Conclusions:

  • Further research is needed to determine if treating hyperuricemia reduces CAD risk.
  • The cardiac safety of pegloticase in CAD patients requires further investigation.
Abstract

Keywords:
GoutNon-steroidal Anti-inflammatory Drugsallopurinolcanakinumabcolchicinecoronary artery diseasecorticosteroidfebuxostatlesinuradpegloticase

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