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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Combination Glioma Therapy Mediated by a Dual-Targeted Delivery System Constructed Using OMCN-PEG-Pep22/DOX

Wenbo Qian1, Min Qian2, Yi Wang3

  • 1Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.

Small (Weinheim an Der Bergstrasse, Germany)
|October 23, 2018
PubMed

Insights

A novel drug delivery system targets glioma cells using polyethylene glycol (PEG) and oxidized nanocrystalline mesoporous carbon particles (OMCN) linked to Pep22. This system combines chemotherapy and photothermal therapy for enhanced glioma treatment.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Receptor-mediated drug delivery is crucial for hydrophobic drugs in glioma chemotherapy.
  • Low-density lipoprotein receptor (LDLR) is a potential target for glioma therapy.

Purpose of the Study:

  • To design and evaluate a novel drug delivery system (OMCN-PEG-Pep22/DOX, OPPD) for targeted glioma treatment.
  • To investigate the dual therapeutic effects of chemotherapy and photothermal therapy mediated by OPPD.

Main Methods:

  • Synthesized a drug delivery vehicle comprising OMCN, PEG, and Pep22 polypeptide targeting LDLR.
  • Loaded doxycycline (DOX) into the system to create OPPD.
  • Evaluated OPPD's targeting efficacy in glioma cells and the blood-brain barrier.
  • Assessed therapeutic efficacy using near-infrared (NIR) irradiation and chemotherapy in a glioma-bearing rat model.
  • Utilized pathological tissue microarrays to correlate LDLR expression with patient survival.

Main Results:

  • OPPD effectively targets LDLR-overexpressing glioma cells and the blood-brain barrier.
  • NIR irradiation of OPPD achieved glioma-killing temperatures in vivo.
  • OPPD significantly reduced glioma sizes compared to control groups.
  • LDLR overexpression in human glioma tissue was associated with patient survival.

Conclusions:

  • The novel OPPD drug-loaded system demonstrates effective targeting of LDLR-overexpressing gliomas.
  • OPPD exerts a dual therapeutic effect through DOX delivery and NIR-induced hyperthermia.
  • OPPD shows promise as a drug delivery vehicle for clinical glioma therapy.
Keywords:
LDLRdual targetingglioma treatmentnanoparticle designthermal therapy

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