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Related Experiment Video

Updated: Feb 3, 2026

Visualization of Cortical Modules in Flattened Mammalian Cortices

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

Lamina-specific cortical dynamics in human visual and sensorimotor cortices.

James J Bonaiuto^1,2, Sofie S Meyer^1,3,4, Simon Little²

¹Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

|October 23, 2018

Summary

Brain activity in different frequency bands (alpha, beta, gamma) shows distinct layer-specific patterns in the cortex. This suggests specialized roles beyond simple feedback and feedforward signaling in sensory and motor processes.

Keywords:

MEG action selection cortical laminae feedback feedforward human neuroscience

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Area of Science:

Neuroscience
Computational Neuroscience
Cognitive Neuroscience

Background:

Cortical networks utilize distinct anatomical and spectral channels for communication.
Alpha and beta frequencies (7-40 Hz) are linked to infragranular layers and feedback, while gamma (>40 Hz) is linked to supragranular layers and feedforward signals.

Purpose of the Study:

To non-invasively test the proposed layer-specific roles of alpha, beta, and gamma activity in human cortical networks using high-precision MEG.
To investigate the functional roles of these frequency channels in sensory and motor processes.

Main Methods:

Utilized high-precision magnetoencephalography (MEG) in human participants.
Recorded brain activity during visually cued actions.

Main Results:

Visual alpha activity was localized to deep cortical laminae.
Visual gamma activity predominantly occurred in superficial cortical layers.
Lamina-specificity was also observed in movement-related sensorimotor beta and gamma activity.

Conclusions:

Distinct frequency channels (alpha, beta, gamma) operate in a lamina-specific manner across the cortex.
These lamina-specific activities suggest more complex functional roles than previously proposed feedback and feedforward signaling.
Frequency-specific cortical activity may fulfill distinct roles in both sensory and motor processes.