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Related Experiment Video

Updated: Feb 3, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
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Brain structural alterations are distributed following functional, anatomic and genetic connectivity.

Franco Cauda1,2, Andrea Nani1,2, Jordi Manuello1,2

  • 1GCS-fMRI, Koelliker Hospital and Department of Psychology, University of Turin, Turin, Italy.

Brain : a Journal of Neurology
|October 23, 2018
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Summary

Brain structural changes in disorders follow network patterns, influenced by connectivity. Functional connectivity best explains these co-alteration patterns, offering insights into neuropathology.

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Systems Biology

Background:

  • Pathological brains exhibit distributed grey matter alterations following network patterns.
  • Voxel-based morphometry (VBM) detects these grey matter changes in various brain disorders.
  • Understanding the network basis of these alterations is crucial for diagnosing and treating brain disorders.

Purpose of the Study:

  • To analyze structural co-alteration patterns across diverse brain disorders using VBM data.
  • To develop a novel method for constructing networks of structurally co-altered brain regions.
  • To compare these pathological networks with functional, anatomical, and genetic connectivity profiles.

Main Methods:

  • Conducted an extensive transdiagnostic search of VBM studies.
  • Devised a method to construct networks of structurally co-altered brain areas.
  • Compared pathological structural co-alteration patterns with functional, anatomical, and genetic connectivity.

Main Results:

  • Structural co-alterations in brain disorders are influenced by connectivity constraints, not random distribution.
  • Functional, anatomical, and genetic connectivity collectively predict the shape and temporal development of co-alteration patterns.
  • Functional connectivity provides the strongest explanation for structural co-alterations, followed by anatomical and genetic connectivity.

Conclusions:

  • Brain structural co-alteration patterns are constrained by underlying connectivity.
  • Functional connectivity plays a dominant role in shaping neuropathological structural changes.
  • These findings advance our understanding of neuropathological mechanisms and brain disorder development.