Chemoselective Pd-Catalyzed C-TeCF3 Coupling of Aryl Iodides
Theresa Sperger1, Sinem Guven1, Franziska Schoenebeck1
1Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Abstract:
While the TeCF3 moiety features promising properties and potential in a range of applications, no direct synthetic method exists for its incorporation into aromatic scaffolds. This report features the first direct catalytic method for the formation of C(sp2 )-TeCF3 bonds. The method relies on a Pd/Xantphos catalytic system and allows for the trifluoromethyltellurolation of aryl iodides. Our computational and experimental mechanistic analyses shed light on the privileged activity of Xantphos in this transformation.
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