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Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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Identifying mild-moderate Parkinson's disease using whole-brain functional connectivity.

Yan Tang1, Bailin Liu2, Yuan Yang3

  • 1School of Information Science and Engineering, Central South University, Changsha, Hunan 410083, China; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|October 23, 2018
PubMed
Summary

This study identifies distinct brain connectivity patterns in mild-moderate Parkinson's disease (PD) patients. These findings aid in distinguishing PD from healthy individuals using functional MRI data.

Keywords:
Locally linear embeddingMultivariate pattern analysisParkinson’s diseaseResting-state functional MRIWhole-brain patterns

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Parkinson's disease (PD) diagnosis often relies on clinical motor symptoms, which may appear after significant neurodegeneration.
  • Understanding early functional brain changes is crucial for timely diagnosis and intervention in PD.

Purpose of the Study:

  • To identify significant disorder-associated patterns in whole-brain functional connectivity.
  • To differentiate individuals with mild-to-moderate Parkinson's disease (PD) from healthy controls using neuroimaging data.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) data were acquired from 36 PD patients and 35 healthy controls.
  • Multivariate pattern analysis was employed to analyze whole-brain functional connectivity patterns.
  • The relationship between functional connectivity asymmetry and the initial symptom side was investigated.

Main Results:

  • A classification accuracy of 80.28% was achieved in distinguishing PD patients from controls using leave-one-out cross-validation.
  • Discriminative functional connectivity was primarily observed within cortical networks, including the default mode, sensorimotor, and attention networks.
  • Patients with initial right-sided symptoms exhibited greater abnormal functional connectivity compared to those with initial left-sided symptoms.

Conclusions:

  • Discriminative functional connectivity patterns are associated with disruptions in cortical networks critical for sensorimotor control and attention.
  • Motor symptom asymmetry in early PD may reflect underlying lateralized brain dysfunction.
  • This research provides novel insights into functional brain alterations in early-stage PD, particularly concerning unilateral motor symptoms.