Related Experiment Video

Updated: Feb 3, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.9K

Abiraterone in metastatic castration-resistant prostate cancer: Efficacy and safety in unselected patients

Grégoire Marret1, Ludovic Doucet1, Christophe Hennequin2

  • 1Department of Cancer Medicine, Hôpital Saint Louis, Paris, France.

Cancer Treatment and Research Communications
|October 23, 2018
PubMed
Abstract

Insights

Abiraterone acetate (AA) provides survival benefits for metastatic prostate cancer (mCRPC) patients. Real-world data show similar toxicity and outcomes to clinical trials, suggesting less intensive monitoring for some patients.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Abiraterone acetate (AA) is a standard treatment for metastatic prostate cancer (mPC).
  • Real-world data on AA toxicity and outcomes in mPC are limited.

Purpose of the Study:

  • To evaluate real-world toxicity and outcomes of abiraterone acetate (AA) in patients with metastatic castration-resistant prostate cancer (mCRPC).

Main Methods:

  • Retrospective study of 93 unselected patients with mCRPC receiving AA plus steroids.
  • Analysis of treatment duration, survival, and adverse events, comparing patients with and without prior chemotherapy.

Main Results:

  • Median AA treatment duration was 7.5 months (pretreated) vs. 12.7 months (chemo-naive).
  • Median survival was 13.4 months (pretreated) vs. 36.4 months (chemo-naive).
  • Adverse event rates (hypokalemia, edema, hypertension, cardiac failure) were similar to Phase 3 trials.

Conclusions:

  • AA demonstrates survival benefits with manageable toxicity in real-world mCRPC patients.
  • Consider reduced monitoring for hypokalemia and liver function if stable for 7.5 and 5.3 months, respectively.
Keywords:
Abiraterone acetateAdverse eventsProstate cancerReal-world practiceSurvival

More Related Videos

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.2K
Murine Prostate Micro-dissection and Surgical Castration08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

47.7K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
396
Self-Efficacy01:29

Self-Efficacy

Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
227
Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K