Related Experiment Video
Updated: Feb 3, 2026
08:43
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
20.3K
Association Between Risk Factors Including Bone-Derived Biomarkers and Aortic Arch Calcification in Maintenance
Kosaku Nitta1, Norio Hanafusa2, Masayuki Okazaki3
1Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japanknitta@twmu.ac.jp.
Kidney & Blood Pressure Research
|October 23, 2018
Summary
Aortic arch calcification is common in maintenance hemodialysis patients. Fibroblast growth factor-23 (FGF-23) levels were linked to calcification severity, suggesting a potential biomarker.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Aortic arch calcification (AoAC) is prevalent in maintenance hemodialysis (MHD) patients.
- AoAC is linked to increased cardiovascular and overall mortality.
Purpose of the Study:
- Investigate factors associated with AoAC in MHD patients.
- Analyze relationships between AoAC and bone-derived biomarkers, including FGF-23 and sclerostin.
Main Methods:
- 389 stable MHD patients were enrolled.
- AoAC assessed via chest X-ray.
- Demographic data and serum levels of sclerostin and FGF-23 were collected.
Main Results:
- 55.5% of patients had AoAC.
- Older age, male gender, and longer dialysis vintage were independent predictors of AoAC.
- Serum FGF-23 levels were inversely associated with AoAC severity and directly with vascular calcification.
Conclusions:
- MHD patients exhibit a high prevalence of AoAC.
- AoAC severity correlates with older age and longer dialysis vintage.
- Circulating FGF-23, not sclerostin, is related to AoAC severity and independently associated with it.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
01:29Factors Affecting Protein-Drug Binding: Patient-Related Factors
325
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
325
01:25Hemodialysis I: Introduction
1.7K
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
1.7K
01:10The Arch of Aorta
1.7K
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
Encircling the heart, the coronary arteries form a ring-like structure before...
1.7K
01:24Hemodialysis II: Procedure and Complications
821
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
821
01:25Hemodialysis III: Nursing Management
884
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
884