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Array-based "Chemical Nose" Sensing in Diagnostics and Drug Discovery.
Yingying Geng1,2, William J Peveler3,4, Vincent M Rotello2
1Molecular and Cellular Biology Program, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA, 01003, USA.
Angewandte Chemie (International Ed. in English)
|October 23, 2018
Summary
Array-based sensors mimic the human nose to identify substances in complex mixtures. These "chemical noses" use multiple elements for pattern recognition, advancing fields like precision medicine.
Area of Science:
- Biomedical Engineering
- Chemical Sensing
- Bioanalytical Chemistry
Background:
- Mammalian olfactory systems inspire array-based sensor platforms.
- These sensors utilize multiple elements for selective analyte interaction and pattern recognition.
- Array-based sensors offer advantages over traditional single-element sensors.
Purpose of the Study:
- To highlight the capabilities of array-based sensors (chemical noses/tongues).
- To discuss their application in chemical biology and clinical pathology.
- To emphasize the role of technological innovation in advancing biomedical goals.
Main Methods:
- Leveraging diverse molecular, bioconjugate, and nanomaterial technologies.
- Designing and analyzing sensor arrays for distinct response patterns.
- Utilizing pattern recognition for analyte identification in complex mixtures.
Main Results:
- Array-based sensors demonstrate proficiency in distinguishing subtle changes within complex mixtures.
- These platforms enable analyte identification through unique response patterns.
- Technological advancements enhance the utility of these sensors.
Conclusions:
- Array-based sensor technology provides a robust toolkit for biomedical research.
- Applications span chemical biology, clinical pathology, and precision medicine.
- Continued innovation in array design and analysis is crucial for future advancements.