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Seroprevalence of Anti-Citrullinated Protein Antibodies (ACPA) in Patients with Rheumatic Diseases other than
Renu Saigal1, Surendra Singh Bhakal2, Laxmikant Goyal3
1Professor and Head, Department of Medicine, Jaipur National University IMSRC, Jaipur, Rajasthan, Former Senior Professor and Head, Department of Medicine, Former In-Charge Rheumatology Services, SMS Medical College, Jaipur, Rajasthan.
Objective:
To evaluate the prevalence of anti- citrullinated protein antibodies (ACPA) in patients with a variety of rheumatic diseases other than rheumatoid arthritis (RA).
Methods:
144 cases of rheumatic diseases other than rheumatoid arthritis (RA) over a period of 1 year were recruited after consenting and followed up for 2 years. Their serum samples were tested for ACPA.
Results:
ACPA seropositivity of 9.03% was observed in rheumatic diseases other than RA.
Conclusion:
Whether ACPA seropositivity in non-RA rheumatic diseases indicates a false positive result or an overlap RA syndrome is a mystery yet unsolved. Long term follow ups of these patients will be required to understand the course of rheumatic diseases in relation to ACPA..
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Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

