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Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
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History and Perspective on DIY Closed Looping.

Dana Lewis1

  • 11 OpenAPS, Seattle, WA, USA.

Journal of Diabetes Science and Technology
|October 24, 2018
PubMed
Summary

Hundreds globally use DIY closed-loop systems for diabetes management, showing positive outcomes in A1c and quality of life. Further research and collaboration are recommended for these innovative diabetes technologies.

Area of Science:

  • Endocrinology and Diabetes Technology
  • Biomedical Engineering
  • Patient-Centered Healthcare Innovations

Background:

  • For decades, individuals with diabetes have modified devices to enhance quality of life and long-term health outcomes.
  • The rise of DIY (Do-It-Yourself) closed-loop systems represents a significant patient-driven innovation in diabetes management.
  • These systems offer unique advantages in transparency, access, and customization compared to commercial alternatives.

Purpose of the Study:

  • To evaluate the initial outcomes and benefits of DIY closed-loop systems used by individuals with diabetes.
  • To document improvements in key glycemic control metrics and quality of life within this community.
  • To highlight the need for further research and collaboration between the DIY community and healthcare providers.
Keywords:
#WeAreNotWaitingAPSOpenAPSartificial pancreasautomated insulin delivery systemclosed loop

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Main Methods:

  • Analysis of outcomes from a global community of individuals using self-modified diabetes devices and DIY closed-loop systems.
  • Review of studies documenting glycemic control (A1c, time in range) and quality-of-life improvements.
  • Consideration of the differences in transparency, access, and usability compared to commercial systems.

Main Results:

  • Positive initial outcomes reported globally across adult and pediatric populations using DIY closed-loop systems.
  • Documented improvements in glycated hemoglobin (A1c) levels and time in range (TIR).
  • Significant quality-of-life benefits observed in users of these self-managed diabetes technologies.

Conclusions:

  • DIY closed-loop systems demonstrate promising results for diabetes management, improving key health metrics.
  • Potential challenges include variability in healthcare provider responses and liability concerns.
  • Further research into quality-of-life impacts and increased collaboration between commercial entities and the DIY community are recommended.