Related Experiment Video
Updated: Feb 3, 2026
07:12
Circadian Entrainment of Drosophila Melanogaster
Published on: June 3, 2020
4.8K
[Surgery and circadian disturbances]
Michael Tvilling Madsen1, Ismail Gögenur
1mitm@regionsjaelland.dk.
Ugeskrift for Laeger
|October 24, 2018
Summary
Surgery disrupts patients' natural body rhythms, impacting recovery and health outcomes. Further studies are needed to explore interventions for mitigating these circadian disturbances during the perioperative period.
Area of Science:
- Chronobiology
- Surgical Research
- Perioperative Medicine
Background:
- Circadian rhythms, encompassing daily cycles of physiological and behavioral processes, are crucial for maintaining homeostasis.
- Extensive research over the past two decades has highlighted the significant impact of surgical interventions on these biological rhythms.
- Disruptions affect key circadian markers including melatonin, core body temperature, cortisol, activity patterns, and sleep architecture.
Purpose of the Study:
- To review the established effects of surgical procedures on circadian rhythmicity.
- To understand the clinical implications of perioperative circadian disturbances on patient recovery and health.
- To identify areas for future research, focusing on diverse surgical contexts and potential mitigation strategies.
Main Methods:
- Literature review of studies investigating circadian rhythm alterations in the perioperative period.
- Analysis of research examining the impact of surgery on hormonal rhythms (melatonin, cortisol), physiological parameters (core body temperature), and behavioral patterns (activity, sleep).
- Synthesis of findings related to patient outcomes, including subjective discomfort, prolonged convalescence, morbidity, and mortality.
Main Results:
- Surgery significantly alters multiple circadian rhythms, including melatonin, core body temperature, cortisol, activity, and sleep.
- These circadian disruptions contribute to adverse patient outcomes such as increased discomfort and extended recovery times.
- Evidence suggests a link between perioperative circadian disturbances and increased clinical morbidity and mortality.
Conclusions:
- Perioperative circadian disturbances represent a significant challenge in surgical patient care, affecting recovery and overall health.
- Further research is warranted to elucidate the specific effects across various surgical procedures.
- Investigating interventions to alleviate these harmful circadian disruptions is a critical next step for improving surgical outcomes.
Related Concept Videos
02:26Ecological Disturbance
21.1K
An ecological disturbance is a temporary disruption in the environment resulting from abiotic, biotic, or anthropogenic factors, causing a pronounced change in an ecosystem. The impact of an ecological disturbance, which can depend on its intensity, frequency, and spatial distribution, plays a significant role in shaping the species diversity within the ecosystem.
21.1K
01:29Disturbances in Heart Rhythm
3.0K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
3.0K
02:19Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
371
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
371
02:17Ecological Succession
21.5K
Ecological succession is influenced by the processes of facilitation, inhibition, and toleration. Facilitation occurs when early successional species create more favorable ecological conditions for subsequent species, such as enhanced nutrient, water, or light availability. In contrast, inhibition happens when early successional species create unfavorable ecological conditions for potential successive species, such as limiting resource availability. In some cases, later successional species...
21.5K
02:27Le Chatelier's Principle: Changing Concentration
65.8K
A system at equilibrium is in a state of dynamic balance, with forward and reverse reactions taking place at equal rates. If an equilibrium system is subjected to a change in conditions that affects these reaction rates differently (a stress), then the rates are no longer equal and the system is not at equilibrium. The system will subsequently experience a net reaction in the direction of a greater rate (a shift) that will re-establish the equilibrium. This phenomenon is summarized by Le...
65.8K