Related Experiment Video
Updated: Feb 3, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
[Update from France Macula Federation: Diagnosis of wet AMD]
1Centre ophtalmologique de la maison rouge, 6, rue de l'Église, 67000 Strasbourg, France.
Purpose:
To update the recommendations of the France Macula Federation for the diagnosis of wet age-related macular degeneration (AMD).
Methods:
Analysis of literature and expert opinion.
Results:
The FMF recommends diagnosing wet AMD by combining the results of fundus examination (or color or monochromatic fundus photographs), optical coherence tomography (OCT) showing exudative signs, and morphological visualization of the neovascular membrane, which may be obtained non-invasively (OCT-angiography) or invasively (fluorescein and/or indocyanine green angiography). Under optimal conditions in which all these tools are available, the FMF recommends using non-invasive methods as first-line tools and resorting to dye angiography if diagnostic doubt remains.
Conclusion:
As observed in other fields of medical imaging, non-invasive methods are preferred to invasive methods for the diagnosis of wet AMD, while the latter are reserved for more difficult cases.
Insights
The France Macula Federation updated its guidelines for diagnosing wet age-related macular degeneration (AMD). Non-invasive imaging like OCT-angiography is now preferred over invasive dye angiography for wet AMD diagnosis.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Wet age-related macular degeneration (AMD) is a leading cause of vision loss.
- Accurate diagnosis is crucial for timely treatment and management.
Purpose of the Study:
- To provide updated recommendations for diagnosing wet AMD.
- To incorporate advancements in imaging technologies.
Main Methods:
- Literature analysis and expert consensus.
- Review of diagnostic imaging techniques for wet AMD.
Main Results:
- Recommends combining fundus examination, optical coherence tomography (OCT) for exudative signs, and neovascular membrane visualization.
- Prioritizes non-invasive methods like OCT-angiography as first-line diagnostic tools.
- Reserves invasive dye angiography (fluorescein/indocyanine green) for cases with diagnostic uncertainty.
Conclusions:
- Non-invasive imaging techniques are increasingly preferred for wet AMD diagnosis.
- Invasive angiography remains valuable for complex or ambiguous cases.
- Updated guidelines aim to improve diagnostic accuracy and patient outcomes.
Related Concept Videos
Nursing Diagnosis
The nursing diagnosis focuses on evidence-based...
Formulating and Validating Nursing Diagnosis I
There are thirteen domains...
Documentation of Nursing Diagnosis
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
Formulating and Validating Nursing Diagnosis II
Risk nursing diagnoses represent clinical judgments of an individual, family, or community more vulnerable to developing the health problem than others...
Diabetes: Symptoms, Diagnosis, and Complications
Role of Communication in the Nursing Process I: Assessment and Diagnosis
The nursing process considers the patient's emotional and physical well-being. The process can be repeated or stopped at any point if judged essential. Assessment is the first step in the nursing...

