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Efficacy of Ceritinib After Alectinib for ALK-positive Non-small Cell Lung Cancer

Hironori Yoshida1, Young Hak Kim2, Hiroaki Ozasa1

  • 1Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

In Vivo (Athens, Greece)
|October 24, 2018
PubMed
Abstract

Insights

Ceritinib shows modest benefit for patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) after alectinib treatment failure. Further investigation is warranted for this ALK-positive NSCLC patient population.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Alectinib is a standard treatment for anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC).
  • Resistance to alectinib develops in most patients, necessitating alternative therapies.
  • Limited data exist on the efficacy of ceritinib following alectinib treatment.

Purpose of the Study:

  • To evaluate the efficacy of ceritinib in patients with ALK-positive NSCLC who progressed on alectinib.
  • To assess treatment outcomes for ceritinib as a subsequent therapy after alectinib failure.

Main Methods:

  • Retrospective review of ALK-positive NSCLC patients treated at Kyoto University Hospital (2012-2017).
  • Identification of patients who received ceritinib after alectinib treatment.
  • Evaluation of overall response rate and progression-free survival for ceritinib.

Main Results:

  • Nine out of 35 ALK-positive NSCLC patients received ceritinib after alectinib.
  • Overall response rate to ceritinib was 44% (16% immediately after alectinib, 100% after chemotherapy).
  • Median progression-free survival with ceritinib was 4.4 months.

Conclusions:

  • Ceritinib demonstrated a modest clinical benefit in patients with ALK-positive NSCLC after alectinib failure.
  • Ceritinib may represent a viable treatment option in this specific clinical setting.
  • Sequential treatment strategies warrant further investigation for advanced NSCLC.
Keywords:
ALK-positiveNon-small cell lung canceralectinibceritinib

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