Related Experiment Video For Hedgehog
Updated: Jun 9, 2026

Using Primary Neurosphere Cultures to Study Primary Cilia
Published on: April 14, 2017
Mixed signals from the cell's antennae: primary cilia in cancer
Thibaut Eguether1, Michael Hahne2
1École Normale Supérieure, CNRS, INSERM, APHP, Laboratoire des Biomolécules (LBM), Sorbonne Université, PSL Research University, Paris, France thibaut.eguether@upmc.fr michael.hahne@igmm.cnrs.fr.
Abstract:
Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as Hedgehog and WNT It is therefore not surprising that a dysfunction of PC is frequently associated with pathologies. Originally, PC were found to be involved in a variety of diseases commonly referred to as ciliopathies including cystic kidney diseases. Evidence is accumulating that PC play also an important role in cancer formation and regulation, which is the focus of this review.
Related Concept Videos
Cancers Originate from Somatic Mutations in a Single Cell
Microtubules in Signaling
Cancer Cell Migration through Invadopodia
Chemotaxis and Direction of Cell Migration
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Cancers Originate from Somatic Mutations in a Single Cell

