Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Necrosis01:16

Necrosis

6.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.6K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
X-ray Crystallography02:18

X-ray Crystallography

26.2K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
26.2K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

64.3K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
64.3K
CRISPR01:59

CRISPR

57.9K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
57.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alveolar type 2 cell LRP1 is needed for surfactant phospholipid metabolism and pulmonary function in mice.

Journal of lipid research·2026
Same author

The role of cell death pathways in respiratory viral infection and vaccination: two sides of the same coin.

Frontiers in immunology·2025
Same author

Retraction Note: Parkin and PINK1 mitigate STING-induced inflammation.

Nature·2025
Same author

Diminishing reactogenicity with preserved immunogenicity in COVID-19 vaccines: A longitudinal observation from primary to updated booster vaccine cohorts.

Journal of infection and public health·2025
Same author

Emulsion adjuvant-induced uric acid release modulates optimal immunogenicity by targeting dendritic cells and B cells.

NPJ vaccines·2025
Same author

Mimicry-based strategy between human and commensal antigens for the development of a new family of immune therapies for cancer.

Journal for immunotherapy of cancer·2025

Related Experiment Video

Updated: Feb 3, 2026

Programmed Electrical Stimulation in Mice
07:29

Programmed Electrical Stimulation in Mice

Published on: May 26, 2010

21.3K

Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation.

Eui Ho Kim1, Sing-Wai Wong1,2, Jennifer Martinez3

  • 1Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, 27709, USA.

Cell Death and Differentiation
|October 24, 2018
PubMed
Summary

Programmed necrosis, unlike apoptosis, is an immunogenic cell death process. Understanding programmed necrosis pathways like necroptosis is crucial for treating inflammatory and autoimmune diseases.

More Related Videos

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data
04:13

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data

Published on: November 13, 2019

12.8K
A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Programmed Electrical Stimulation in Mice
07:29

Programmed Electrical Stimulation in Mice

Published on: May 26, 2010

21.3K
Computer-based Multitaper Spectrogram Program for Electroencephalographic Data
04:13

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data

Published on: November 13, 2019

12.8K
A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.6K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Medicine

Background:

  • Apoptosis is a silent cell death, while necrosis appears chaotic.
  • Emerging evidence reveals programmed forms of necrosis with regulatory functions.
  • Programmed necrosis pathways are inherently more immunogenic than apoptosis.

Purpose of the Study:

  • To highlight the programmed nature of certain necrotic cell death pathways.
  • To emphasize the immunogenic role of programmed necrosis in homeostasis and immunity.
  • To underscore the importance of understanding these mechanisms for disease therapy.

Main Methods:

  • Review of molecular mechanisms underlying programmed necrosis.
  • Analysis of the role of inflammatory cytokines and DAMPs release.
  • Investigation of impaired dead cell clearance and its inflammatory consequences.

Main Results:

  • Programmed necrosis pathways (necroptosis, pyroptosis, ferroptosis, NETosis) release inflammatory mediators.
  • These pathways contribute to a pro-inflammatory state.
  • Impaired clearance of necrotic cells exacerbates inflammation.

Conclusions:

  • Programmed necrosis plays a significant role in immunity and homeostasis.
  • Dysregulation of programmed necrosis is implicated in inflammatory and autoimmune diseases.
  • Detailed understanding of programmed necrosis mechanisms is vital for therapeutic advancements.