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Castleman's disease in the HIV-endemic setting
Esam-Rajab Mahroug1, Candice Sher-Locketz1, Minodora-Silvia Desmirean2,3
1Division of Haematology, Department of Pathology, University of Stellenbosch, Tygerberg Academic Hospital, Cape Town, South Africa.
Cancer Management and Research
|October 24, 2018
Summary
Castleman
Area of Science:
- Hematology
- Oncology
- Infectious Diseases
Background:
- Castleman's disease (CD) is a rare lymphoproliferative disorder with unknown pathogenesis.
- This study investigates the incidence and characteristics of CD.
- Focus on HIV-associated multicentric CD in South Africa.
Purpose of the Study:
- Determine the incidence of Castleman's disease diagnoses over an 11-year period.
- Describe demographic, laboratory, and pathological features of CD.
- Investigate the association between HIV and CD.
Main Methods:
- Retrospective study design.
- Data retrieved from Tygerberg Academic Hospital electronic records and the Tygerberg Lymphoma Study Group.
- Statistical analysis of diagnosed CD cases.
Main Results:
- Fifty-four CD cases diagnosed over 11 years.
- High prevalence of HIV-positive patients (51/53).
- Kaposi sarcoma co-occurrence in 13 cases; bone marrow findings included plasmocytosis.
Conclusions:
- Castleman's disease is a rare polyclonal B-cell lymphoproliferative disorder.
- Significant increase in HIV-associated multicentric CD incidence observed.
- Highlights the importance of HIV status in CD diagnosis and management.