Related Experiment Video

Updated: Feb 3, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

4.1K

Circular RNA Expression in Oral Squamous Cell Carcinoma

Yu-Fan Wang1, Bo-Wen Li1,2, Shuai Sun1

  • 1Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, China.

Frontiers in Oncology
|October 24, 2018
PubMed

Insights

Researchers identified specific circular RNAs (circRNAs) that are altered in oral squamous cell carcinomas (OSCCs). Down-regulated circRNAs, including circ_000334, may play a role in OSCC development.

Area of Science:

  • Molecular Biology
  • Genomics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are key regulators in cellular networks, interacting with microRNAs (miRNAs).
  • Dysregulation of circRNAs is implicated in various cancers, but their role in oral squamous cell carcinoma (OSCC) requires further investigation.

Purpose of the Study:

  • To identify differentially-expressed circRNAs in oral squamous cell carcinoma (OSCC) tissues.
  • To explore the potential role of specific circRNAs in OSCC oncogenesis and progression.

Main Methods:

  • High-throughput sequencing and microarray analysis of circRNA expression profiles.
  • Comparison of circRNA expression between 8 OSCC patients and 8 healthy controls.
  • Validation of differentially-expressed circRNAs in a larger cohort of 42 OSCC patient samples.

Main Results:

  • Identification of 1921 known and 10021 novel circRNA molecules.
  • Discovery of eight differentially-expressed circRNAs (up-regulated and down-regulated) in OSCC.
  • Significant down-regulation of circ_000334, circ_006740, and circ_006371 in OSCC tissues.

Conclusions:

  • circ_000334, circ_006740, and circ_006371 are significantly down-regulated in oral squamous cell carcinoma.
  • These circRNAs may function as tumor suppressors and are potentially involved in the development and progression of OSCC.
Keywords:
Oral squamous cell carcinomacircRNAsnoncoding RNAoncogenesispathological differentiation

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

840
Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma12:03

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

20.0K

Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.5K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.7K
Deformation in a Circular Shaft01:10

Deformation in a Circular Shaft

One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
924
Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.1K
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.1K