[Parenteral nutrition and concentrated amino acid solution]

The authors report on their experience with a solution of amino acids concentrated at 25 gomegaN/liter in eighty patients on exclusive and total parenteral nutrition (TPN). The average duration of the TPN is 35.08 days. Azonutril 25 was given as nutritive melange, maintaining a calorie-nitrogen ratio of 150 to 200 calories for every added gram of nitrogen. The clinical and biological studies provide a series of arguments in favor of such an amino acid solution in total parental nutrition in patients with acute or chronic digestive insufficiency. No signs of renal or hepatic intolerance have appeared during this study. The improvement in nitrogen balance in fifteen patients is strongly significant (P less than 0.001) and can be correlated with weight gain and with the classic immunological tests.