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Related Experiment Videos

Lymphocyte abnormalities in ankylosing spondylitis.

P T Fan, P J Clements, D T Yu

    Annals of the Rheumatic Diseases
    |October 1, 1977
    PubMed
    Summary
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    Ankylosing spondylitis patients showed lower T lymphocyte percentages, suggesting an increased

    Area of Science:

    • Immunology
    • Rheumatology

    Background:

    • Ankylosing spondylitis is a chronic inflammatory disease.
    • Immune system dysregulation is implicated in its pathogenesis.

    Purpose of the Study:

    • To investigate peripheral blood lymphocyte subpopulations in ankylosing spondylitis patients.
    • To compare T and B lymphocyte levels and phytohaemagglutinin (PHA) responsiveness between patients and healthy controls.

    Main Methods:

    • Assayed T (SRBC rosette) and B (AgG- and C-receptor) lymphocyte subpopulations.
    • Measured phytohaemagglutinin (PHA) responsiveness.
    • Compared results between 40 ankylosing spondylitis patients and 55 normal subjects.

    Main Results:

    • No significant difference in overall lymphocyte concentrations or PHA responsiveness.

    Related Experiment Videos

  • Significantly lower percentages of T lymphocytes in ankylosing spondylitis patients.
  • Normal percentages of B lymphocyte subpopulations (AgG- and C-receptor cells).

    • Conclusions:

    • The reduced T lymphocyte percentage in ankylosing spondylitis may be attributed to an increase in the 'null' lymphocyte population.
    • This finding suggests a specific alteration in lymphocyte subsets in ankylosing spondylitis, independent of HLA type.