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Updated: Feb 3, 2026

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
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Identification of a novel KLC1-ROS1 fusion in a case of pediatric low-grade localized glioma

Yoshiko Nakano1,2, Arata Tomiyama3,4, Takashi Kohno5

  • 1Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. yonakano@ncc.go.jp.

Brain Tumor Pathology
|October 24, 2018
PubMed

Insights

A novel KLC1-ROS1 fusion was found in pediatric low-grade glioma. This oncogenic fusion, driven by the proto-oncogene tyrosine-protein kinase ROS1 (ROS1), showed sensitivity to the ALK/ROS1 inhibitor crizotinib.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The proto-oncogene tyrosine-protein kinase ROS1 (ROS1) is a receptor tyrosine kinase structurally similar to anaplastic lymphoma kinase receptor (ALK).
  • ROS1 rearrangements are implicated in various cancers, but their role in pediatric gliomas is less understood.
Keywords:
CrizotinibFISHImmunohistochemistryKLC1–ROS1 fusionPediatric glioma

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