Metabolomic correlates of aerobic capacity among elderly adults

Aerobic capacity is a powerful predictor of cardiovascular disease and all-cause mortality, and it declines with advancing age.

Since physical activity alters body metabolism, metabolism markers will likely differ between subjects with high vs low aerobic capacities.

Community-based participants without physician-diagnosed heart disease, stroke or cancer underwent same-day multimodal assessment of cardiovascular function (by echocardiography and magnetic resonance feature tracking of left atrium) and aerobic capacity by peak oxygen uptake (VO₂ ) metrics. Associations between VO₂ and cardiovascular and metabolomics profiles were studied in adjusted models including standard covariates.

We studied 141 participants, of whom 82 (58.2%) had low VO₂ , while 59 (41.8%) had high VO₂ . Compared to participants with high VO₂ , participants with low VO₂ had more adverse cardiovascular parameters, such as lower ratio of peak velocity flow in early diastole to peak velocity flow in late diastole by atrial contraction of >0.8 (76% vs 35%, adjusted odd ratio [OR] = 4.1, 95% confidence interval [CI] [1.7-9.5], P = 0.001) and lower left atrial conduit strain (11.3 ± 4.0 vs 15.6 ± 6.1%, adjusted OR = 1.1, 95% CI [1.002-1.3], P = 0.045). High VO₂ was associated with lower accumulation of wide-spectrum acyl-carnitines (OR = 0.6, 95% CI [0.4-0.9], P = 0.013), alanine (OR = 0.1, 95% CI [0.01-0.9], P = 0.044) and glutamine /glutamate (OR = 0.1, 95% CI [0.01-0.5], P = 0.007), compared to low VO_2. CONCLUSION: Elderly adults with low VO₂ have adverse cardiovascular and metabolic parameters compared to their counterparts with high VO₂ . Combined cardiac and metabolomics phenotyping may be a promising tool to provide insights into physiological states, useful for tracking future interventions related to physical activity among community cohorts.