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Microtubular Dysfunction and Male Infertility

Sezgin Gunes1,2, Pallav Sengupta3,2, Ralf Henkel4,2

  • 1Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

The World Journal of Men'S Health
|October 24, 2018
PubMed

Insights

Microtubules are essential for sperm function and male fertility. This review details their structure, role in sperm development, and links between microtubule dysfunction and male infertility.

Area of Science:

  • Cell Biology
  • Reproductive Biology
  • Biochemistry

Background:

  • Microtubules are key cytoskeletal components alongside microfilaments.
  • They are vital for organelle transport and cell division during spermatogenesis.
  • Microtubule-based structures like the axoneme and manchette are critical for sperm morphology.

Purpose of the Study:

  • To provide a structural overview of microtubules.
  • To analyze the role of microtubule structures in male reproductive functions.
  • To explore the association between microtubule dysfunctions and male infertility.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of structural and functional roles of microtubules in sperm.
  • Synthesis of current knowledge on microtubule-related male infertility.

Main Results:

  • Microtubules are fundamental for sperm motility and functional capacity.
  • Specific microtubule structures are crucial for sperm head and tail formation.
  • Microtubular dysfunctions are linked to various forms of male infertility.

Conclusions:

  • Microtubules play indispensable roles in sperm formation and function.
  • Understanding microtubule dynamics is crucial for diagnosing and treating male infertility.
  • Further research into microtubule-related mechanisms can advance male infertility studies.
Keywords:
AxonemeInfertility, maleKartagener syndromeMicrotubule-associated proteins

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