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Tumor suppressors BTG1 and BTG2: Beyond growth control

Laurensia Yuniati1,2, Blanca Scheijen1,3, Laurens T van der Meer1

  • 1Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands.

Journal of Cellular Physiology
|October 24, 2018
PubMed

Insights

B-cell translocation gene 1 (BTG1) and BTG2 are key antiproliferation genes involved in cell division and DNA repair. Their deregulation is linked to cancer progression, highlighting their tumor suppressor roles and potential clinical implications.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • B-cell translocation gene 1 (BTG1) and BTG2 identified as antiproliferation genes over 20 years ago.
  • BTG proteins regulate cell division, DNA repair, transcription, mRNA stability, and differentiation.
  • They are crucial for maintaining homeostasis during cellular stress.

Purpose of the Study:

  • To review current knowledge on BTG1 and BTG2 functions in cellular processes.
  • To highlight their roles in stress responses and hematopoiesis.
  • To discuss the implications of BTG1 and BTG2 deregulation in cancer.

Main Methods:

  • Literature review of studies on BTG1 and BTG2.
  • Analysis of genomic profiling data in B-cell malignancies.
  • Examination of expression levels in solid tumors.

Main Results:

  • BTG1 and BTG2 are frequently deleted/mutated in B-cell leukemia and lymphoma, suggesting tumor suppressor activity.
  • Reduced BTG1/BTG2 expression correlates with malignant behavior and poor outcomes in solid tumors.
  • Novel roles in genotoxic, integrated stress responses, and hematopoiesis uncovered.

Conclusions:

  • BTG1 and BTG2 are critical regulators of cellular processes with significant tumor suppressor functions.
  • Deregulation of BTG1 and BTG2 contributes to cancer progression through various molecular mechanisms.
  • Understanding these roles may lead to new clinical strategies for cancer treatment.
Keywords:
B-cell malignanciesBTG1BTG2antiproliferationtumor suppressor

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