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Related Concept Videos

Proteomics01:33

Proteomics

9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
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Extraction: Advanced Methods00:56

Extraction: Advanced Methods

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

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Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
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Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

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Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
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Related Experiment Video

Updated: Feb 3, 2026

Digital Microfluidics for Automated Proteomic Processing
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Digital Microfluidics for Automated Proteomic Processing

Published on: November 6, 2009

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Advancing single-cell proteomics and metabolomics with microfluidic technologies.

Yifan Liu1, Xuyue Chen, Yiqiu Zhang

  • 1Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu Province 215123, China. jliu@suda.edu.cn.

The Analyst
|October 24, 2018
PubMed
Summary
This summary is machine-generated.

Single-cell omics analysis reveals cell diversity. Microfluidics-based platforms are advancing single-cell proteomics and metabolomics for deeper biological insights.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • Single-cell analysis reveals heterogeneity beyond genomics and transcriptomics.
  • Investigating cellular behavior requires broader 'omics' approaches like proteomics and metabolomics.
  • Efficient isolation of single cells is crucial for multi-omics studies.

Purpose of the Study:

  • To review recent advances in single-cell proteomics and metabolomics.
  • To focus on the role of microfluidics-based platforms in these fields.
  • To highlight emerging microfluidic formats and analytical tool integrations.

Main Methods:

  • Review of microfluidics-based platforms for single-cell isolation and manipulation.
  • Integration of state-of-the-art analytical tools with microfluidic systems.
  • Analysis of proteomic and metabolomic profiling techniques at the single-cell level.

Main Results:

  • Emerging microfluidic formats enable efficient single-cell isolation and manipulation.
  • Various analytical tools are being coupled with microfluidic platforms for advanced profiling.
  • Significant progress has been made in single-cell proteomics and metabolomics.

Conclusions:

  • Microfluidics is a key enabling technology for single-cell multi-omics.
  • Advanced single-cell proteomics and metabolomics offer dynamic cellular insights.
  • Future research will likely see further integration of microfluidics and omics for comprehensive cell analysis.