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Related Experiment Video

Updated: Feb 3, 2026

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate
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[Combined subchronic toxicity of nickel and manganese oxides nanoparticles, and its decrease due to bioprotectors

I A Minigalieva, L I Privalova, M P Sutunkova

    Meditsina Truda I Promyshlennaia Ekologiia
    |October 24, 2018
    PubMed
    Summary

    Nickel and manganese oxide nanoparticles are toxic, with Mn3O4 causing more harm, potentially modeling Parkinson's disease. A bioprotector complex reduced their combined toxicity and genotoxicity in rats.

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    Area of Science:

    • Nanotechnology
    • Toxicology
    • Neuroscience

    Background:

    • Nickel oxide (NiO) and manganese tetroxide (Mn3O4) nanoparticles are synthesized via laser ablation.
    • These nanoparticles were administered intraperitoneally to rats to assess their toxicological effects.

    Purpose of the Study:

    • To evaluate the toxicity of NiO and Mn3O4 nanoparticles, individually and in combination.
    • To investigate the neuroprotective effects of a bioprotector complex against nanoparticle-induced toxicity.
    • To establish an experimental model for manganese-induced parkinsonism.

    Main Methods:

    • Intraperitoneal injection of NiO and Mn3O4 nanoparticles (16.7±8.2 nm and 18.4±5.4 nm) into rats.
    • Administration of a bioprotector complex (pectin, vitamins A, C, E, glutamate, glycine, N-acetylcysteine, selenium, iodine, omega-3 fatty acids) to a separate group.
    • Assessment of intoxication via functional parameters, histological changes in organs (liver, spleen, kidneys, brain), and metal accumulation measurements.

    Main Results:

    • Both NiO and Mn3O4 nanoparticles exhibited toxicity, with Mn3O4 showing more pronounced nonspecific toxicity.
    • Nanoparticles caused significant neuronal injury in the caudate nucleus and hippocampus, suggesting a model for manganese parkinsonism.
    • The bioprotector complex significantly diminished the organic, systemic toxicity, and genotoxicity of combined Mn3O4 and NiO nanoparticle exposure.

    Conclusions:

    • NiO and Mn3O4 nanoparticles pose health risks, particularly neurotoxicity.
    • The studied bioprotector complex offers a potential countermeasure against nanoparticle-induced toxicity and genotoxicity.
    • The findings support the use of this bioprotector complex in mitigating the adverse effects of these metallic oxide nanoparticles.