Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Catalysis02:50

Catalysis

30.5K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
30.5K
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

10.7K
For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
10.7K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

260
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
260
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

205
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
205
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

218
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
218

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secondary organic aerosol formation from linalool-derived Criegee intermediates: mechanistic insights into Criegee-carbonyl cycloadditions and atmospheric implications.

Physical chemistry chemical physics : PCCP·2026
Same author

Tetrazole Synthesis via Cyclopropenium Phase-Transfer Catalysis: A Click Strategy.

Organic letters·2026
Same author

Dependence of the Electrochemical Behavior of Redox-Functionalized Calix[4]arene Monolayers on Intermolecular Interactions in a Structurally Controlled Interfacial Architecture.

ACS applied materials & interfaces·2026
Same author

Catalytic Enantioselective Synthesis of 1,1-Disubstituted Isochromans.

Journal of the American Chemical Society·2026
Same author

Nickel and copper complexes of a new multidentate ligand: synthesis, characterization and magneto-structural investigations.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Lewis Acid-Initiated Cleavage of a Large Ionophore: Molecular Deactivation by Potassium Ion Binding.

ChemMedChem·2025

Related Experiment Video

Updated: Feb 3, 2026

The Effect of Ultraviolet Radiation on the Chemical Bath Deposition of Bisthiourea Cadmium Chloride Crystals and the Subsequent CdS Obtention
05:21

The Effect of Ultraviolet Radiation on the Chemical Bath Deposition of Bisthiourea Cadmium Chloride Crystals and the Subsequent CdS Obtention

Published on: August 30, 2018

7.8K

Cyclopropenium Enhanced Thiourea Catalysis.

Ivor Smajlagic1, Rocio Durán1, Melanie Pilkington1

  • 1Brock University , 1812 Sir Isaac Brock Way , St. Catharines , Ontario L2S 3A1 , Canada.

The Journal of Organic Chemistry
|October 24, 2018
PubMed
Summary

This study reports a novel thiourea-cyclopropenium organocatalyst for pyranylation reactions. This catalyst efficiently promotes reactions with diverse alcohols and phenols under mild conditions, showcasing its broad applicability in organocatalysis.

More Related Videos

Hot Biological Catalysis: Isothermal Titration Calorimetry to Characterize Enzymatic Reactions
13:00

Hot Biological Catalysis: Isothermal Titration Calorimetry to Characterize Enzymatic Reactions

Published on: April 4, 2014

21.4K
Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination
11:16

Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination

Published on: August 18, 2020

6.0K

Related Experiment Videos

Last Updated: Feb 3, 2026

The Effect of Ultraviolet Radiation on the Chemical Bath Deposition of Bisthiourea Cadmium Chloride Crystals and the Subsequent CdS Obtention
05:21

The Effect of Ultraviolet Radiation on the Chemical Bath Deposition of Bisthiourea Cadmium Chloride Crystals and the Subsequent CdS Obtention

Published on: August 30, 2018

7.8K
Hot Biological Catalysis: Isothermal Titration Calorimetry to Characterize Enzymatic Reactions
13:00

Hot Biological Catalysis: Isothermal Titration Calorimetry to Characterize Enzymatic Reactions

Published on: April 4, 2014

21.4K
Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination
11:16

Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination

Published on: August 18, 2020

6.0K

Area of Science:

  • Organic Chemistry
  • Catalysis

Background:

  • Thiourea catalysts are essential in modern organocatalysis.
  • Developing novel organocatalysts with unique properties is an ongoing research area.

Purpose of the Study:

  • To synthesize a novel thiourea-cyclopropenium organocatalyst.
  • To evaluate the catalyst's utility in pyranylation reactions.
  • To investigate the catalytic mechanism.

Main Methods:

  • Synthesis of a bifunctional thiourea-cyclopropenium catalyst.
  • Pyranylation reactions with various alcohols and phenols.
  • Kinetic studies, 1H NMR binding, and DFT calculations for mechanistic analysis.

Main Results:

  • Successful synthesis of the thiourea-cyclopropenium organocatalyst.
  • Demonstrated broad substrate scope in pyranylation reactions under mild conditions.
  • Identified benzoic acid as a valuable co-catalyst for specific substrates.
  • Mechanistic studies supported a Brønsted acid catalysis pathway.

Conclusions:

  • The developed thiourea-cyclopropenium catalyst is effective for pyranylation.
  • Cooperative catalysis with benzoic acid enhances reaction efficiency for challenging substrates.
  • The catalyst operates via a Brønsted acid mechanism.